Chlorpheniramine Maleate for Dogs: Uses, Dosage, and Safety

When it comes to the health and well-being of our beloved furry friends, it's essential to have access to effective medications that can alleviate their discomfort and improve their quality of life. Chlorpheniramine maleate is a commonly used antihistamine that can be beneficial for dogs suffering from allergies and other related conditions. In this article, we will explore the uses, dosage guidelines, and safety considerations of Chlorpheniramine maleate for dogs.

What is Chlorpheniramine?

Chlorpheniramine maleate is an antihistamine that blocks the effects of histamine, a chemical released by the body during allergic reactions. It is commonly used in both humans and animals to relieve symptoms such as itching, sneezing, runny nose, and watery eyes associated with allergies. In veterinary medicine, Chlorpheniramine maleate is often prescribed to dogs suffering from allergic dermatitis, insect bites, food allergies, and respiratory allergies. Oral administration. The drug takes effect within two hours and lasts for about 4-6 hours

What is Chlorpheniramine Maleate Used For?

1. Allergic Dermatitis

Dogs can develop allergic reactions to various allergens, including pollen, dust mites, certain foods, and flea bites. Chlorpheniramine maleate helps alleviate itching, inflammation, and other discomforts associated with allergic dermatitis.

2. Respiratory Allergies

Dogs may experience respiratory allergies, such as hay fever or asthma, leading to symptoms like sneezing, coughing, and difficulty breathing. Chlorpheniramine maleate can provide relief by reducing inflammation and constriction of the airways.

3. Insect Bites

Insect bites and stings can trigger an allergic response in dogs, causing itchiness and localized swelling. Chlorpheniramine maleate can help alleviate these symptoms and minimize discomfort.

4. Cold

Chlorpheniramine maleate is sometimes used to alleviate symptoms associated with the common cold, such as sneezing, nasal congestion, and postnasal drip. However, it may not be as effective as other medications specifically designed for cold relief.

How Does Chlorpheniramine Maleate Work for Dogs?

When dogs are exposed to allergens, such as pollen, dust mites, or certain foods, their immune system can trigger the release of histamines. Histamines are substances that play a key role in allergic reactions. They bind to specific receptors in the body, causing various symptoms associated with allergies. In dogs, the common histamines involved in allergic reactions are H1 Receptors, H2 Receptors, H3 Receptors, and H4 Receptors.

Histamine H1 receptors are found in smooth muscle cells, blood vessels, and nerve endings. When histamine binds to these receptors, it can cause symptoms such as itching, inflammation, sneezing, and increased mucus production.

Histamine H2 receptors are primarily found in the stomach lining, where they stimulate the secretion of gastric acid. In dogs, the H2 receptors are not as well-studied as in humans and are believed to have a lesser role in allergic reactions compared to H1 receptors.

Histamine H3 receptors are mainly located in the central nervous system, where they act as autoreceptors and regulate the release of histamine and other neurotransmitters. They have a modulatory role and are involved in regulating neurotransmitter activity in the brain.

Histamine H4 receptors are found on immune cells and play a role in regulating the immune response, inflammation, and cell migration. They are particularly involved in allergic skin reactions.

Chlorpheniramine maleate blocks the action of histamine. By blocking histamine, it helps reduce or alleviate allergic symptoms in dogs.

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How Much Chlorpheniramine Maleate Can I Give My Dog?

Always follow veterinary instructions and product use directions. The dosage of chlorpheniramine maleate for dogs can vary depending on the size, weight, and individual needs of the dog. It is crucial to consult with a veterinarian before giving any medication to your dog, including chlorpheniramine. The veterinarian will consider your dog's specific condition and provide you with the appropriate dosage instructions.

As a general guideline, the typical recommended dosage of chlorpheniramine for dogs is:

• For small dogs (under 20 pounds or approximately 9 kilograms): 2-4 milligrams every 8-12 hours.

• For medium-sized dogs (20-50 pounds or approximately 9-23 kilograms): 4-8 milligrams every 8-12 hours.

• For large dogs (over 50 pounds or approximately 23 kilograms): 8-12 milligrams every 8-12 hours.

Chlorpheniramine is available in different strengths (e.g., 4 mg, 8 mg), so be sure to carefully check the label and select the appropriate strength as recommended by your veterinarian.

Overdose Information for Chlorpheniramine

Chlorpheniramine should always be administered to dogs according to the prescribed dosage provided by a veterinarian. Overdosing on chlorpheniramine can be dangerous and potentially life-threatening for dogs.

The signs of an overdose of chlorpheniramine in dogs may include:

• Extremely drowsy or lethargic

• Weakness

• Lack of coordination

• Stumbling

• Increased heart rate

• Dilated pupils

• Dry mouth

• Vomiting

• Diarrhea

• Loss of appetite

If an overdose is suspected, the veterinarian may induce vomiting or perform gastric lavage to remove unabsorbed paracetamol from the dog's system and administer intravenous fluids to maintain hydration and support organ function or activated charcoal to bind and prevent further absorption of the drug.
Following emergency treatment, the vet will also closely monitor the dog's vital signs including heart rate, blood pressure and respiratory rate.

Precautions and Side Effects

Precautions

Allergies and sensitivities: Inform your veterinarian if your dog has any known allergies or sensitivities to antihistamines or other medications. Certain breeds, such as Collies, may be more susceptible to adverse reactions to certain drugs, including antihistamines.

Underlying health conditions: Dogs with certain health conditions, such as glaucoma, high blood pressure, urinary obstruction, heart disease, or thyroid issues, may require special consideration or alternative treatment options. Make sure to disclose your dog's complete medical history to the veterinarian.

Pregnancy and lactation: The use of chlorpheniramine maleate in pregnant or nursing dogs should be approached with caution and only under the guidance of a veterinarian.

Side Effects

The most common side effect of this medication is drowsiness. Additional side effects include:

• dizziness

• confusion

• constipation

• vomiting

• anxiety

• nausea

• blurred vision

• restlessness

• decreased coordination

• dry mouth

• shallow breathing

• hallucinations

• irritability

• tinnitus and trouble urinating

Other Key Points

• Paracetamol does not require a prescription but should be taken under the supervision of a licensed veterinarian

• Chlorpheniramine is generally inexpensive and widely accessible.

• Oral administration. The drug takes effect within two hours and lasts for about 4-6 hours.

• In the treatment of allergic skin diseases, antihistamines and omega-3 fatty acid supplements have a synergistic effect and as a general rule in the treatment of this disease it is best to use these drugs together.

• Chlorpheniramine maleate should not be used in conjunction with other sedative drugs.

What is The Best Chlorpheniramine Maleate?

• Puainta® Chlorpheniramine Maleate Allergic Itch Relief for Dogs and Cats

Puainta allergy medication comes in the form of convenient tablets that are designed to provide quick relief, combat itching, promote rapid and complete absorption, and offer long-lasting results.

• Puainta medicated formula is quickly absorbed by the body, ensuring rapid allergy relief in 15 minutes.

• Enjoy extended relief as our medication provides a sustained effect, minimizing the recurrence of allergy symptoms.

• By utilizing Chlorpheniramine Maleate, an antihistamine commonly used to control itching in dogs and cats, our medication works to desensitize your pet's immune system and reduce allergic reactions.

Important Safety Information

Chlorpheniramine Maleate tablets are forbidden for dogs/cats less than 3 months old.

Doxylamine Succinate vs Chlorpheniramine Maleate

Doxylamine succinate and chlorpheniramine maleate are both antihistamine medications that are commonly used to relieve symptoms associated with allergies, hay fever, and the common cold. While they have similar uses and mechanisms of action, there are some differences between the two.

Mechanism of action

Both doxylamine succinate and chlorpheniramine maleate work by blocking histamine receptors in the body, thereby reducing the allergic response. They belong to a class of antihistamines known as first-generation antihistamines.

Sedating effects

Doxylamine succinate is known for its sedating effects and is often used as a sleep aid due to its ability to induce drowsiness. It is commonly found in over-the-counter sleep aids. Chlorpheniramine maleate, on the other hand, can also cause drowsiness but is generally considered to have less sedating effects compared to doxylamine succinate.

Over-the-counter availability

Both doxylamine succinate and chlorpheniramine maleate are available over the counter in various formulations, including tablets, capsules, and syrups. However, it's important to follow the recommended dosage and usage instructions provided on the packaging or as directed by a healthcare professional.

Chlorpheniramine Storage

Chlorpheniramine should be stored at room temperature, typically between 15 to 30 degrees Celsius (59 to 86 degrees Fahrenheit). Avoid storing it in the bathroom or any other areas with high humidity. It is generally recommended to store it in a dark place, such as a cupboard or drawer.

When storing chlorpheniramine, ensure that it is in a child-proof container or a place that is out of reach of children. This helps prevent accidental ingestion, as antihistamines can be harmful if taken in large amounts.

It is often advisable to keep chlorpheniramine in its original packaging or container to retain important information such as expiration date, dosage instructions, and warnings.

Check the expiration date on the packaging of chlorpheniramine and do not use it beyond that date. Expired medications may not be as effective and could potentially be harmful.

FAQs

Is Chlorpheniramine Maleate Safe During Pregnancy?

Chlorpheniramine maleate is generally considered safe to use during pregnancy, but it is always important to consult with a healthcare professional before taking any medications during pregnancy.

Does Chlorpheniramine Maleate Increase Blood Pressure?

Some dogs individuals may experience a slight increase in blood pressure when taking chlorpheniramine due to its anticholinergic effects. Anticholinergic drugs can potentially raise blood pressure by interfering with the normal functioning of the autonomic nervous system.

Does Chlorpheniramine Maleate Cause Drowsiness in Dogs?

Yes, chlorpheniramine maleate can cause drowsiness in dogs. Chlorpheniramine is an antihistamine that is commonly used in veterinary medicine to treat allergic reactions and relieve symptoms such as itching, sneezing, and runny nose in dogs.