Feline Kidney Lymphoma

Feline kidney lymphoma, also known as renal lymphoma in cats, is an aggressive cancer that affects the kidneys. It is one of the most common types of feline lymphoma and can spread to other organs, including the spleen, liver, and central nervous system (CNS).

Since feline kidney lymphoma symptoms often mimic those of chronic kidney disease (CKD) or urinary tract infections (UTIs), it can be challenging to diagnose. This article will provide an in-depth look at feline kidney lymphoma, covering its symptoms, diagnosis, treatment options, and prognosis. We will also discuss how it differs from kidney disease and how feline leukemia virus (FeLV) plays a role in increasing lymphoma risk.

What Is Feline Kidney Lymphoma?

Lymphoma is a type of cancer of the lymphatic system, which includes the lymph nodes, spleen, and other immune-related tissues. When it affects the kidneys, it is called renal lymphoma.

Is Feline Kidney Lymphoma Different from Other Kidney Diseases?

Feline kidney lymphoma is a cancer, while conditions like chronic kidney disease (CKD) and kidney infections (UTIs) are non-cancerous but still affect kidney function. Both conditions may cause similar symptoms, such as increased thirst, weight loss, and vomiting, making proper diagnosis crucial.

How Feline Leukemia Virus (FeLV) Increases Lymphoma Risk

FeLV is a viral infection that weakens the immune system and increases the likelihood of developing renal lymphoma in cats. Studies show that FeLV-positive cats are at a significantly higher risk of developing lymphoma than FeLV-negative cats. This is why regular FeLV testing is essential for all cats.

Feline Kidney Lymphoma Symptoms

The symptoms of renal lymphoma in cats are often mistaken for kidney disease. Since the kidneys play a critical role in filtering toxins and maintaining fluid balance, any disruption can lead to severe health issues.

Common Symptoms of Feline Kidney Lymphoma:

✔️ Increased thirst and urination (polydipsia and polyuria)
✔️ Loss of appetite and weight loss
✔️ Lethargy and weakness
✔️ Vomiting and diarrhea
✔️ Dehydration despite drinking more water
✔️ Abdominal pain or swelling

If your cat shows these signs, a veterinary checkup is crucial to rule out kidney disease and confirm whether lymphoma is present.

How Is Renal Lymphoma in Cats Diagnosed?

Veterinarians use multiple tests to differentiate kidney lymphoma from kidney disease or infections:

♦Blood Tests – To check kidney function and detect abnormal white blood cells.
♦Urinalysis – To look for protein loss or other kidney abnormalities.
♦Imaging (Ultrasound/X-rays) – To detect enlarged kidneys or tumors.
♦Fine-Needle Aspiration or Biopsy – A kidney tissue sample confirms lymphoma.

Since kidney lymphoma symptoms overlap with kidney disease, a biopsy is often required for a definitive diagnosis.

Feline Kidney Lymphoma Treatment

Since surgery is not an option for kidney lymphoma, the primary treatment is chemotherapy, which helps slow down the cancer and improve the cat’s quality of life.

1. Chemotherapy (CHOP Protocol)

The CHOP protocol is the most effective chemotherapy treatment and consists of:
✅ Cyclophosphamide – Slows cancer growth.
✅ Doxorubicin – Kills lymphoma cells.
✅ Vincristine – Prevents cancer cell division.
✅ Prednisolone (steroid) – Reduces inflammation.

Cats generally tolerate chemotherapy better than humans, but some may experience mild side effects such as nausea or lethargy.

2. Supportive Care

Because kidney function is already compromised, supportive care is essential:
✔️ IV Fluids – Helps with hydration and kidney support.
✔️ Appetite Stimulants – Medications like mirtazapine encourage eating.
✔️ Pain Management – If needed, pain relievers improve comfort.

3. Radiation Therapy

Radiation is not commonly used but may help if the lymphoma spreads to the spinal cord or brain.

Can Feline Kidney Lymphoma Be Cured?

Most cases of renal lymphoma in cats are not curable, but remission is possible with chemotherapy. Cats in remission can enjoy several months to a year of improved quality of life.

Feline Kidney Lymphoma Prognosis

How Long Can a Cat Live With Renal Lymphoma?

The prognosis for feline kidney lymphoma depends on several factors:

• FeLV status – FeLV-positive cats have a shorter survival time.
• Response to chemotherapy – Cats that respond well can live much longer.
• Overall health of the cat – Younger, healthier cats tolerate treatment better.

Survival Estimates:

• With chemotherapy – Most cats live 3 to 9 months, but some survive over a year.
• Without treatment – Survival is only a few weeks to a month.

Is Feline Kidney Lymphoma Preventable?

While there is no guaranteed way to prevent renal lymphoma, you can reduce your cat’s risk by:

• ✔️ Testing for FeLV and FIV – Prevent FeLV-positive cats from spreading the virus.
  ✔️ Providing a High-Quality Diet – Supports the immune system and overall health.
  ✔️ Regular Vet Checkups – Early detection is key to better outcomes.

Best Diet for Cats With Kidney Disease or Cancer

If your cat has kidney lymphoma or kidney disease, their diet should focus on:
✔️ Low phosphorus levels – Reduces kidney strain.
✔️ High-quality protein – Easily digestible to maintain muscle mass.
✔️ Omega-3 fatty acids – Helps with inflammation.
✔️ Increased hydration – Wet food or added water to meals is beneficial.

Commercial diets like Hill’s Prescription Diet k/d or Royal Canin Renal Support can support kidney function while providing proper nutrition.

Early Signs of Feline Lymphoma Every Cat Owner Should Know

♦Persistent weight loss and appetite loss
♦Increased thirst and urination
♦Chronic vomiting or diarrhea
♦Lethargy and overall weakness

Catching lymphoma early improves treatment success. If you notice these signs, consult your vet immediately.

Final Thoughts

Feline kidney lymphoma is a serious and aggressive cancer, but with early diagnosis and chemotherapy, many cats achieve months or even years of remission. If your cat shows symptoms like increased thirst, weight loss, or vomiting, seek veterinary care immediately.

Key Takeaways:

◊Renal lymphoma in cats is a serious but treatable condition.
◊Symptoms often mimic kidney disease, making diagnosis tricky.
◊Chemotherapy is the best treatment for extending survival.
◊With treatment, cats can live 3 to 9 months or longer.

By understanding feline kidney lymphoma symptoms, treatment, and prognosis, you can provide your cat with the best possible care and quality of life.